Children and youth across East and Southern Africa continue to face devastating challenges to their social and emotional (psychosocial) wellbeing, which also translates into poor social, health and educational outcomes. The region is still the epicentre of the HIV epidemic. 12 of the countries REPSSI works in have the highest adult HIV prevalence rates in the world, and AIDS is now the leading cause of death in adolescents in sub-Saharan Africa. While treatment and prevention measures have brought huge gains, stigma and discrimination continue to plague efforts to end the epidemic.